{"created":"2023-06-19T11:10:31.136987+00:00","id":185,"links":{},"metadata":{"_buckets":{"deposit":"4442d680-d3ba-4103-a1e7-001f549eb986"},"_deposit":{"created_by":3,"id":"185","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"185"},"status":"published"},"_oai":{"id":"oai:shijonawate-gakuen.repo.nii.ac.jp:00000185","sets":["43:60"]},"author_link":["1430"],"control_number":"185","item_3_biblio_info_12":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008","bibliographicIssueDateType":"Issued"},"bibliographicNumberOfPages":"17","bibliographicPageEnd":"51","bibliographicPageStart":"35","bibliographicVolumeNumber":"4","bibliographic_titles":[{"bibliographic_title":"四條畷学園大学リハビリテーション学部紀要","bibliographic_titleLang":"ja"},{"bibliographic_title":"Annual reports of Faculty of Rehabilitation, Shijonawate Gakuen University","bibliographic_titleLang":"en"}]}]},"item_3_description_10":{"attribute_name":"抄録(日)","attribute_value_mlt":[{"subitem_description":"In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration. Analysis of the characteristics of RA-induced malformation showed that many of them arose from the lumbosacrocaudal region of the axial skeleton. Based on these results, the present study was focused on the elucidation of the pathogenesis of spina bifida. All-trans RA was administered at dose of 60 mg/kg to pregnant DA rats at 10 days of gestation, and its influence on the posterior neuropore of embryos was examined serially by morphological methods. As a result, neural plate elevation was impaired at 6-9 h after RA administration, and neuroepithelial eversion occurred 12 h after administration. Thereafter, neuroepithelial eversion due to neuroepithelial overgrowth occurred, presumbly leading to the development of spina bifida.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_3_description_8":{"attribute_name":"論文種類","attribute_value_mlt":[{"subitem_description":"原著","subitem_description_language":"ja","subitem_description_type":"Other"},{"subitem_description":"Original","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_3_identifier_registration":{"attribute_name":"ID登録","attribute_value_mlt":[{"subitem_identifier_reg_text":"10.15110/0000000185","subitem_identifier_reg_type":"JaLC"}]},"item_3_publisher_22":{"attribute_name":"公開者・出版者","attribute_value_mlt":[{"subitem_publisher":"四條畷学園大学","subitem_publisher_language":"ja"}]},"item_3_source_id_1":{"attribute_name":"収録物識別子","attribute_value_mlt":[{"subitem_source_identifier":"AA12130337","subitem_source_identifier_type":"NCID"},{"subitem_source_identifier":"18806856","subitem_source_identifier_type":"PISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{}],"affiliationNames":[{"affiliationName":"Shijonawate Gakuen University","affiliationNameLang":"en"},{"affiliationName":"四條畷学園大学","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Konishi, Hiroyoshi","creatorNameLang":"en"},{"creatorName":"小西, 啓悦","creatorNameLang":"ja"},{"creatorName":"コニシ, ヒロヨシ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"Konishi","familyNameLang":"en"},{"familyName":"小西","familyNameLang":"ja"},{"familyName":"コニシ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"Hiroyoshi","givenNameLang":"en"},{"givenName":"啓悦","givenNameLang":"ja"},{"givenName":"ヒロヨシ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1430","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2016-02-25"}],"displaytype":"detail","filename":"KJ00005321539.pdf","filesize":[{"value":"11.3 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KJ00005321539.pdf","url":"https://shijonawate-gakuen.repo.nii.ac.jp/record/185/files/KJ00005321539.pdf"},"version_id":"abeaf8ad-def2-488e-bd8c-79a1efad4223"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"retinoic acid","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"spina bifida","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"neuroepithelium","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"rat embryo","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Pathogenesis of retinoic acid-induced spina bifida in rat embryos","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Pathogenesis of retinoic acid-induced spina bifida in rat embryos","subitem_title_language":"en"}]},"item_type_id":"3","owner":"3","path":["60"],"publish_date":"2008-01-01","publish_status":"0","recid":"185","relation_version_is_last":true,"title":["Pathogenesis of retinoic acid-induced spina bifida in rat embryos"],"weko_creator_id":"3","weko_shared_id":-1},"updated":"2024-04-24T05:39:23.747439+00:00"}