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Pathogenesis of retinoic acid-induced spina bifida in rat embryos
https://doi.org/10.15110/0000000185
https://doi.org/10.15110/0000000185bb0940ad-23b4-48a6-b797-46a9c7974674
名前 / ファイル | ライセンス | アクション |
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KJ00005321539.pdf (11.3 MB)
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Item type | 紀要論文 / Departmental Bulletin Paper(1) | |||||||||||
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資源タイプ | ||||||||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||
資源タイプ | departmental bulletin paper | |||||||||||
言語 | ||||||||||||
言語 | eng | |||||||||||
論文種類 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | 原著 | |||||||||||
言語 | ja | |||||||||||
論文種類 | ||||||||||||
内容記述タイプ | Other | |||||||||||
内容記述 | Original | |||||||||||
言語 | en | |||||||||||
タイトル | ||||||||||||
言語 | en | |||||||||||
タイトル | Pathogenesis of retinoic acid-induced spina bifida in rat embryos | |||||||||||
抄録 | ||||||||||||
内容記述タイプ | Abstract | |||||||||||
内容記述 | In a previous study, we showed that the intrauterine exposure of rat embryos to retinoic acid (RA) in the organogenesis period (8-11 days of gestation) induced various malformations according to the dose and timing of RA administration. Analysis of the characteristics of RA-induced malformation showed that many of them arose from the lumbosacrocaudal region of the axial skeleton. Based on these results, the present study was focused on the elucidation of the pathogenesis of spina bifida. All-trans RA was administered at dose of 60 mg/kg to pregnant DA rats at 10 days of gestation, and its influence on the posterior neuropore of embryos was examined serially by morphological methods. As a result, neural plate elevation was impaired at 6-9 h after RA administration, and neuroepithelial eversion occurred 12 h after administration. Thereafter, neuroepithelial eversion due to neuroepithelial overgrowth occurred, presumbly leading to the development of spina bifida. | |||||||||||
言語 | en | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | retinoic acid | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | spina bifida | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | neuroepithelium | |||||||||||
キーワード | ||||||||||||
言語 | en | |||||||||||
主題Scheme | Other | |||||||||||
主題 | rat embryo | |||||||||||
著者 |
小西, 啓悦
× 小西, 啓悦
WEKO
1430
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ID登録 | ||||||||||||
ID登録 | 10.15110/0000000185 | |||||||||||
ID登録タイプ | JaLC | |||||||||||
アクセス権 | ||||||||||||
アクセス権 | open access | |||||||||||
アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||
書誌情報 |
ja : 四條畷学園大学リハビリテーション学部紀要 en : Annual reports of Faculty of Rehabilitation, Shijonawate Gakuen University 巻 4, p. 35-51, ページ数 17, 発行日 2008 |
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収録物識別子 | ||||||||||||
収録物識別子タイプ | NCID | |||||||||||
収録物識別子 | AA12130337 | |||||||||||
収録物識別子 | ||||||||||||
収録物識別子タイプ | PISSN | |||||||||||
収録物識別子 | 18806856 | |||||||||||
公開者・出版者 | ||||||||||||
言語 | ja | |||||||||||
出版者 | 四條畷学園大学 |